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GNE-371 Catalog No.:M22638-C CAS Number: 206986-79-0

SKU: 81966166623

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Description

CAS Number: 206986-79-0

Solubility: DMSO : 150 mg/mL (219

Formula: C22H21N3O3

Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC50 of 684±159 nM and >1

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

GNE-371 Catalog No.:M22638-C CAS Number: 206986-79-0GNE 371 is a potent and selective chemical probe for the second bromodomains of human transcription initiation factor TFIID subunit 1 and transcription initiation factor TFIID subunit 1 like, with an IC50 of 10 nM for TAF1(2). GNE 371 (compound 27) binds TAF1(2) with an IC50 of 10 nM while maintaining excellent selectivity over other bromodomain family members. GNE 371 is also active in a cellular TAF1(2) target engagement assay (IC50=38 nM) and

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